Research Paper Volume 15, Issue 19 pp 10767—10784
Modified iPOND revealed the role of mutant p53 in promoting helicase function and telomere maintenance
Figure 4. The p53S endowed the cellular resistance to G4 stabilizer treatment. (A) The cell cycle analysis revealed the G2 arrest induced by 20 μM PDS treatment, the p53null cells were most sensitive while the p53S cells were not sensitive. (B) The Annexin V staining displayed the cellular apoptosis induced by 20 μM PDS treatment. The p53null cells were most sensitive to PDS treatment, while p53S endowed the cell’s resistance to PDS treatment. (C) The DNA helicase protein level decreased after 20 μM PDS treatment, while p53S still maintained high level of DNA helicase. (D) The quantification of protein expression level in (C).