Research Paper Volume 15, Issue 19 pp 10767—10784
Modified iPOND revealed the role of mutant p53 in promoting helicase function and telomere maintenance
Figure 3. The p53S protected the cells from G4 stabilizer PDS induced DNA damages. (A) The presence of DNA damage related γ-H2AX foci induced by 10 μM or 20 μM of G4 stabilizer PDS in WT, p53null, p53S, and p53H cells. The p53null and the p53H cells showed stronger γ-H2AX signals compared with WT cells, and p53S cells displayed less γ-H2AX signals than WT cells. (B) The quantification of γ-H2AX signal in (A).