Research Paper Volume 15, Issue 19 pp 9984—10009

Figure 2. BMAL1 is localized at AP-1 binding sites in senescence. (A) Experimental outline for collection and culturing of cells, senescence induction and collection. (B) Differential binding between control and senescent cells identified by BMAL1-ChIP-seq. (C, D) Top motifs enriched in senescent cells (C) and control cells (D). (E) Gene ontology of pathways up- and downregulated in BMAL1-ChIP-seq targets in senescent cells. n = 3 replicates for BMAL1-ChIP-seq.