Research Paper Volume 15, Issue 20 pp 11114—11130

Figure 6. β-catenin is required for NKD1-mediated protection against PAH. (A) The relative protein level of β-catenin in dissected PAs of MCT-treated mice after transfection of Ad-Con or Ad-Nkd1 was assessed by western blotting (post hoc for LSD test; n = 6 samples). MCT-treated mice were transfected with Ad-Con or Ad-Nkd1 and treated with or without SKL2001. RVSP (B) and RVHI (C) of above-treated mice were measured (post hoc for LSD test; n = 6 samples). (D) Representative H-E staining pictures of lung tissues in above-treated mice were shown. The black arrows indicate peripheral PAs of lung tissues. Bar = 50 μm. Data were shown as mean ± S.D. ^**P < 0.01 and ^***P < 0.001 denoted statistical comparison between the two marked groups, respectively.