Research Paper Volume 15, Issue 19 pp 10593—10606
UCHL1-PKM2 axis dysregulation is associated with promoted proliferation and invasiveness of urothelial bladder cancer cells
Figure 1. The expression levels of UCHL1 are frequently up-regulated in UBC tissues and is positively associated with advanced clinical stage and poor outcomes in UBC patients. (A, B) WB detection of UCHL1 protein expression pattern in 36 matched sample pairs of UBC tumor and adjacent normal tissues. (C) PCR detection of UCHL1 mRNA expression pattern in 36 matched sample pairs of UBC tumor and adjacent normal tissues. (D, E) IHC method detection and IHC score comparison of UCHL1 protein expression pattern in normal adjacent tissues and UBC tumor tissues (n = 3). (F, G) UCHL1 mRNA expression comparison between UBC patient subgroups with different N-T stages. (H–L) UCHL1 mRNA expression comparison between UBC patient subgroups with different pathological stages, M stages, lympho-vascular invasion status and histologic grade. (M–O) Kaplan-Meier analysis on the correlation of UCHL1 expression level with UBC patients’ prognostic endpoints including overall survival, disease-specific survival and progression free survival.