Research Paper Volume 15, Issue 19 pp 10540—10548
Sonic hedgehog signaling promotes angiogenesis of endothelial progenitor cells to improve pressure ulcers healing by PI3K/AKT/eNOS signaling
Figure 4. SHH pathway improves pressure ulcers healing in the rat model. (A, B) The pressure ulcers rat model was constructed, and the rats were treated with EPCs, or SAG or cyclopamine-treated EPCs, respectively. (A) The wound injury was analyzed by H&E staining in the rats. The representative wound healing images were shown. N = 5. (B) The pressure ulcers rat model was constructed, and the rats were treated with EPCs, or SAG or cyclopamine-treated EPCs, respectively. The angiogenesis was analyzed by the accumulation of CD31 based on immunofluorescent analysis in the rats. N = 5.