Research Paper Volume 15, Issue 19 pp 10524—10539
Paroxetine protects against bleomycin-induced pulmonary fibrosis by blocking GRK2/Smad3 pathway
Figure 3. PRXT treatment ameliorated lung pathological injury and improved survival rate in bleomycin-induced mice. (A) Representative images of H&E staining and Masson staining in the indicated groups (n=5). (B, C) Inflammation score and fibrosis score based on H&E staining and Masson staining (n=5). (D) Survival rate of each group (n=10). *P < 0.05 vs. the Control group, #P < 0.05 vs. the PF group. PF, pulmonary fibrosis. PRTX-L, Paroxetine-Low dose (2.5 mg·kg−1·day−1). PRTX-M, Paroxetine-Medium dose (5 mg·kg−1·day−1). PRTX-H, Paroxetine-High dose (7.5 mg·kg−1·day−1).