Research Paper Volume 15, Issue 19 pp 10428—10452
Mitochondrial dysfunction following repeated administration of alprazolam causes attenuation of hippocampus-dependent memory consolidation in mice
Figure 5. Effects of Alp on mitochondrial function in the hippocampal neurons. (A, B) Alp causes changes in MMP (n = 6). (C) Mitochondrial OCR was assessed 48 h post-treatment with Alp (n = 3). Parameters of mitochondrial function, (D) maximal respiration, and (E) proton leak, were calculated based on the OCR values. (F) Repeated Alp administration (1.84 mg/kg) alters the mitochondrial morphology in mouse hippocampal tissue. Data are presented as mean ± SEM, *p < 0.05, **p < 0.01 vs. control. (A) Scale bar is 10 μm. (B) scale bar is 1 μm.