Research Paper Volume 15, Issue 19 pp 10237—10252
Ginkgolide attenuates memory impairment and neuroinflammation by suppressing the NLRP3/caspase-1 pathway in Alzheimer’s disease
Figure 7. Ginkgolides attenuated pathological alterations in the hippocampus and cerebral cortex of APP/PS1 mice. Ginkgolides alleviated (A) inflammatory cell infiltration (H&E, ×400, scale bar = 50 μm), (B) neuron loss (Nissl staining, ×400, scale bar = 50 μm), and (C) the accumulation of Aβ in the brains of APP/PS1 mice shown by immunohistochemistry (×200; scale bar = 50 μm). Abbreviations: Aβ: amyloid beta; APP/PS1: amyloid precursor protein/presenilin 1; H&E: Hematoxylin and Eosin; WT: wild-type.