Figure 2.Impact of reduced double-strand DNA break repair on endothelium-dependent and independent vasodilation. (A) Mesenteric artery dose-response curves to increasing doses of the endothelium-dependent vasodilator acetylcholine in the absence and presence of the nitric oxide synthase inhibitor L-NAME. N = 7–11 per group. (B) Maximal acetylcholine (ACh) vasodilation in mesenteric arteries in the absence and presence of L-NAME. N = 7–11 per group. (C) Mesenteric artery dose-response curves to increasing doses of the endothelium-independent vasodilator sodium nitroprusside. Yg = young. N = 8–10 per group. Individual data points with black borders denote female mice. Individual data points matching group colors denote male mice. †p < 0.05 vs. Acetylcholine dose-response curve in the absence of L-NAME from the same group.
