Research Paper Volume 15, Issue 21 pp 11697—11719
Longitudinal characterization of behavioral, morphological and transcriptomic changes in a tauopathy mouse model
Figure 4. Transcriptomic analysis revealed genome-wide alterations in the hippocampus of P301S mice at different ages. (A, D) Venn-diagrams showing the significantly up-regulated (A) or down-regulated (D) genes in P301S mice at 3 months and 9 months. (B, E) Heatmaps representing expression (row z-score) of genes that were up-regulated (B) or down-regulated (E) in P301S mice exclusively at 3 months, compared to age-matched WT samples (n = 5 mice/group). (C, F) GO Biological Process analysis of up-regulated genes (C) or down-regulated genes (F) in P301S mice exclusively at 3 months.