Research Paper Volume 15, Issue 16 pp 8444—8457
m6A methyltransferase METTL16 mediates immune evasion of colorectal cancer cells via epigenetically regulating PD-L1 expression
Figure 4. METTL16 modulates immune invasion in a CRC cell/T cell co-culture system. CRC cells were co-cultured with unstimulated or activated T cells. (A) The portion of PD-1+/CD4+ T cells and PD-1+/CD8+ T cells was measured by flow cytometry. (B) Cell viability was assessed by CCK-8 assay. (C) Cell apoptosis was measured by flow cytometry. **p<0.01.