Research Perspective Volume 15, Issue 14 pp 6632—6640
Towards disease-oriented dosing of rapamycin for longevity: does aging exist or only age-related diseases?
Figure 1. Relations between aging and age-related diseases (ARDs). (A) Aging is caused by accumulation of molecular damage. ARDs are caused by external causes. Aging is a just a risk factor for ARDs. Humans die from aging (grey skull), unless they die earlier from ARDs (red skull). (B) Hyperfunction theory of quasi-programmed aging. Aging is a continuation of developmental growth, driven in part growth-promoting pathways such as mTOR and MAPK. Aging is manifested by ARDs, which kill a person. (C) Hyperfunction theory of quasi-programmed ARDs. ARDs are a continuation of developmental growth, driven in part by growth-promoting pathways such mTOR and MAPK.