Research Paper Volume 15, Issue 14 pp 7219—7236

Figure 3. The construction of MRSs and enrichment analysis. (A) Forest plot of the univariate Cox regression analysis for MRGs. (B) LASSO regression and stepwise multivariate Cox regression were used to construct the five-MRG signature. (C) Kaplan-Meier survival analysis of patients. (D) ROC curve analysis of the five-MRG signature. (E) Expression patterns of MRSs in high-and low-risk groups. (F, G) Forrest plot of the independent prognostic factors in OS. (H–J) Nomogram for predicting the 1-, 3-, and 5-years OS of osteosarcoma patients. (I) Calibration curves for validating the established nomogram. (J) The ROC curves of the nomograms compared for 1-, 3-, and 5-years OS in osteosarcoma patients, respectively. (K, L) Circle plot through Gene Ontology (GO) analysis visualizing the biological processes enriched by DEGs. (L) GO analysis of differentially expressed genes between the high- and low-risk groups. (M) Differences in risk scores between distinct survival status and the proportion of survival status of patients.