Research Paper Volume 15, Issue 14 pp 7161—7186

Identification and validation of a novel overall survival prediction model for immune-related genes in bone metastases of prostate cancer

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Figure 8. Up-regulation of MAVS suppressed PCa cells’ proliferation and metastasis. (A) MAVS expression of primary (n=22) and bone metastasis (n=20) of PCa in GSE77930. (B) The OS analysis of MAVS expression in the training and validation cohorts. (C) Relative MAVS mRNA expression in the PCa cell line. (D, E) Overexpression efficiency of MAVS in PC-3 and DU-145 cells by RT-qPCR and capillary immunoblotting. (F) Assessment of proliferation ability in PC-3 and DU-145 cells with MAVS (controls and mimics) via MTT assay. The original blots are provided in Supplementary Figure 5. *P <0.05, **P <0.01, *** P < 0.001.