Research Paper Volume 15, Issue 14 pp 6950—6968
Single-cell sequencing analysis reveals the relationship between tumor microenvironment cells and oxidative stress in breast cancer bone metastases
Figure 5. Clonal evolution of fibroblast subpopulations in patients with bone metastases from breast cancer. (A, B) Pseudo-time values (A) and developmental trajectories (B) of fibroblast subpopulations, with pie charts representing the proportion of fibroblast subpopulations in control and breast cancer bone metastasis patients. (C) Co-expression modules of transcription factors in fibroblast subpopulations of patients with breast cancer bone metastases. Left: Identification of regulator modules based on the regulator’s linkage specificity index matrix. Middle: representative transcription factors and their binding patterns in the modules. Right panel: cell subpopulations in which transcription factors are located. (D) Single-cell atlas showing transcription factors regulating fibroblast subpopulations.