Research Paper Volume 15, Issue 14 pp 6905—6920

Figure 7. exo-PD regulates mitochondrial oxidative phosphorylation pressure, mitochondrial membrane potential and cellular senescence state in intestinal epithelial cells. (A) Mitochondrial oxidative respiratory pressure test. (B) Oxidative respiratory pressure of HIEC-6 after 8 Gy irradiation and 24 h incubation with the addition of PBS, PD solution, exosome solution and exo-PD solution. (C) exo-PD ameliorates the decrease in mitochondrial membrane potential of intestinal epithelial cells. (D) exo-PD retarded the senescence of intestinal epithelial cells. (E) The ratio of IOD between monomer and aggregates about mitochondrial membrane potential. (F) The IOD of β-galactosidase staining of intestinal epithelial cells in IR group, IR+PD group and IR+exo-PD group. ^* represents p < 0.05, ^** represents p < 0.01, ^*** represents p < 0.001, and ^**** is p < 0.0001, indicating that the differences are statistically significant.