Research Paper Volume 15, Issue 13 pp 6400—6428
Exploring Cancer Dependency Map genes and immune subtypes in colon cancer, in which TIGD1 contributes to colon cancer progression
Figure 3. Comparison of five CDM genes model with other models. (A, B) The ROC curve of signatures in TCGA-COAD cohort. (A) Li signature (ten genes). Green show one year AUC value (AUC value=0.572), blue show three years AUC value (AUC value=0.578) and red show five years AUC value (AUC value=0.579). (B) Nie signature (five genes). Green show one year AUC value (AUC value=0.648), blue show three years AUC value (AUC value=0.664) and red show five years AUC value (AUC value=0.684). (C) Ren signature (eight genes). Green show one year AUC value (AUC value=0.598), blue show three years AUC value (AUC value=0.668) and red show five years AUC value (AUC value=0.604). (D) Xu signature (eight gene). Green show one year AUC value (AUC value=0.631), blue show three years AUC value (AUC value=0.642) and red show five years AUC value (AUC value=0.727). (E–H) Kaplan-Meier plot in all TCGA –COAD cohort (p<0.001). Survival curves for high (blue) and low (green) risk groups dichotomized at the median of risk score are plotted. (E) shows Li signature (p=0.344), (F) shows Nie signature (p<0.001), (G) shows Ren signature (p=0.007) and (H) shows Xu signature (p=0.007). (I) The ROC curve of CDM signature in all TCGA-COAD cohort. Green show one year AUC value (AUC value=0.700), blue show three years AUC value (AUC value=0.740) and red show five years AUC value (AUC value=0.764). (J) Kaplan-Meier plot in all TCGA –COAD cohort (p<0.001). Survival curves for high (blue) and low (green) risk-CDM groups dichotomized at the median of risk-CDM score are plotted. (K) C-index of the five prognostic risk models. The higher the C-index, and the more reliable the signature. Red shows CDM risk signature (C-index=0.697). Yellow shows Li signature (C-index=0.566). Cyan shows Nie signature (C-index=0.634). Blue shows Ren signature (C-index=0.605), Dull red shows Xu signature (C-index=0.621). (L) The RMS analysis of the five prognostic risk signature. Red shows CDM risk signature. Yellow shows Li signature. Cyan shows Nie signature. Blue shows Ren signature, Dull red shows Xu signature.