Research Paper Volume 15, Issue 13 pp 6380—6399
DSC2 suppresses the growth of gastric cancer through the inhibition of nuclear translocation of γ-catenin and PTEN/PI3K/AKT signaling pathway
Figure 7. DSC2 inhibited the PI3K/AKT signaling pathway in MGC-803 cells. After stably expressing and knocking down DSC2 gene in MGC-803 cells, (A, B) the expressions of PTEN, pro-PI3K, p-PI3K, pro-AKT, p-AKT were detected by Western blot assay. Data are presented as mean ± SEM from three separate experiments. ***p<0.001 vs. BC. ###p<0.001 vs. Si-NC or Lenti-NC. (C) The expressions of DSC2, γ-catenin, p-PI3K and p-AKT in tumor xenograft tissues were detected by Western blot assay. Data are presented as mean ± SEM, n=5. ***p<0.001 vs. sgRNA-NC. ###p<0.001 vs. Lenti-NC.