Research Paper Volume 15, Issue 12 pp 5854—5872
iPSC-derived exosomes promote angiogenesis in naturally aged mice
Figure 7. Comparison of serum exosomal proteins between old and young mice groups. (A, B) Gene ontology (GO) functional annotation of up- and down-regulated exosomal proteins in old serum group, respectively. (C, D) Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis of upregulated and downregulated exosomal proteins in old serum group. (E) GO functional annotation of upregulated exosomal proteins in old mice pre-injected with iPSC-exosomes. (F) GO functional annotation of the downregulated exosomal proteins in old mice pre-injected with iPSC-exosomes. (G) KEGG pathway enrichment analysis of upregulated exosomal proteins of old mice pre-injected with iPSC-exosomes. (H) KEGG pathway enrichment analysis of downregulated exosomal proteins of old mice pre-injected with iPSC-exosomes. BP, biological process; MF, molecular function; CC, cellular component.