Research Paper Volume 15, Issue 12 pp 5279—5289
A novel peptide ‘T14’ reflects age and photo-aging in human skin
Figure 3. Effect of UV-light on levels of T14 in skin. (A) Immunohistochemistry of AChE T14 peptide expression is higher in aged photo-protected (50 to 70 years old) skin compared to photo-aged skin (50 to 70 years old. N=10 in each group. (B) Average number of epidermal cells with a positive AChE T14 peptide antibody stain. Aged (photo-protected) skin samples have a significantly higher expression (p value of 0.00265) of T14 positive cells compared to its expression in age matched, photo-aged skin samples. (C) Average number of epidermal cells with a positive AChE T14 peptide antibody stain normalized by epidermal area. Aged (photo-protected) skin samples have a significantly higher expression (p value of 0.00176) of T14 positive cells per epidermal area compared to its expression in age-matched photo-exposed skin. (D) Immunohistochemistry of AChE T14 peptide expression is higher in 1 outlier of the aged group.