Research Paper Volume 15, Issue 13 pp 6179—6211
ZNF765 is a prognostic biomarker of hepatocellular carcinoma associated with cell cycle, immune infiltration, m6A modification, and drug susceptibility
Figure 2. The expression of ZNF765 in HCC and other cancers. (A) ZNF765 mRNA levels in tumor and normal tissues based on the TCGA database (p = 9.061e-12). (B) Paired differential expression map of ZNF765 between 72 pairs of HCC tissues and normal tissues based on the TCGA database (p = 3.845e-08). (C) The mRNA expression level of ZNF765 in tumor and normal tissues in the ICGC (p = 2.22e-16). (D) HCMDB analysis of aberrant expression of ZNF765 in HCC patients. (E) Typical images of immunohistochemistry (IHC) in 40 pairs of HCC tissues showing the protein expression of ZNF765 in HCC and adjacent nontumor tissues. Colonies formed by HCCLM3 (F) and SMCC7721 (G) cells transfected with control shRNA or shRNA targeting ZNF765. The panels are a quantification of the results of the colony formation assay (**p < 0.01). (H) Representative data from Transwell migration and invasion assays performed with the ZNF765 knock-down cells.