Research Paper Volume 15, Issue 12 pp 5698—5712
Sevoflurane upregulates neuron death process-related Ddit4 expression by NMDAR in the hippocampus
Figure 3. Cell death-related biological processes were significantly enriched by differentially expressed genes. (A) Five cell death-related biological processes were significantly enriched by differentially expressed genes. (B) Thirteen differentially expressed genes (10 genes upregulated in the sevoflurane-treated group and 3 genes downregulated in the sevoflurane-treated group) were significantly enriched in positive regulation of cell death. (C) Ten differentially expressed genes (8 genes upregulated in the sevoflurane-treated group and 2 genes downregulated in the sevoflurane-treated group) were significantly enriched in the regulation of neuronal death. (D) Seven differentially expressed genes (6 genes upregulated in the sevoflurane-treated group and 1 gene downregulated in the sevoflurane-treated group) were significantly enriched in the negative regulation of neuronal death. (E) Nine differentially expressed genes (7 genes upregulated in the sevoflurane-treated group and 2 genes downregulated in the sevoflurane-treated group) were significantly enriched in the regulation of neuronal apoptosis. (F) Seven differentially expressed genes (6 genes upregulated in the sevoflurane-treated group and 1 gene downregulated in the sevoflurane-treated group) were significantly enriched in the negative regulation of neuronal apoptosis. (Red: up regulated DEGs; blue: down regulated DEGs).