Research Paper Volume 15, Issue 12 pp 5569—5591

Figure 3. Genetic variation characteristics of SP100 family members in PAAD and relationship of their expression levels with m6A methylation regulators and TP53 mutation status. (A) Genetic variation characteristics of the SP100 family members in PAAD; (B) The amplification and mRNA High mutation of SP100 was significantly correlated with PAAD patients have a family history of breast cancer; (C–E) The amplification and mRNA High mutation of SP110/SP140/SP140L was significantly correlated with PAAD invasion of surrounding tissues; (F) The promoter methylation level of SP100/SP140L in the TP53 mutant PAAD tissue was significantly lower than that in the TP53 wild-type PAAD tissue; (G) The expression level of SP100/SP110/SP140L in the TP53 mutant PAAD tissue was significantly higher than that in the TP53 wild-type PAAD tissue.