Research Paper Volume 15, Issue 12 pp 5412—5425
Tumor-suppressive function and mechanism of miR-873-5p in glioblastoma: evidence based on bioinformatics analysis and experimental validation
Figure 7. Schematic representation of the mechanism of miR-873-5p in GBM. miR-873-5p targets HMOX1 and inhibits its expression, thus downregulating the HIF1α/SPOP signaling axis, reducing the proliferation and invasion as well as the tumorigenesis of GBM cells.