Research Paper Volume 15, Issue 10 pp 3984—4011
Stress granules sequester Alzheimer’s disease-associated gene transcripts and regulate disease-related neuronal proteostasis
Figure 6. Changes in RNA levels after the depletion of G3BP1 and G3BP2, and AS-treatment in SH-SY5Y. (A, B) Scatter plot depicting RNA abundance in G3BP1-depleted (A) and G3BP2-depleted cells (B). Red, blue, and gray dots indicate genes upregulated, downregulated, and unchanged upon knockdown, respectively. siCtrl indicates control knockdown. (C–F) Pie charts depicting the relative contribution of gene categories for upregulated (C and E) and downregulated (D and F) genes upon depletion of G3BP1 and G3BP2, respectively. (G and H) Intersections for upregulated or downregulated genes of protein-coding genes (G) and lncRNAs (H) upon knockdown. (I–L) Intersections across upregulated, downregulated genes upon knockdown and enriched RNAs based on eCLIP-seq and SG RNA-seq of protein-coding genes.