Research Paper Volume 15, Issue 9 pp 3791—3806
microRNA-497 slows esophageal cancer development and reverses chemotherapy resistance through its target QKI
Figure 6. miR-497 overexpression inhibits tumor growth and QKI expression in vivo. (A, B) Overexpression of miR-497 inhibited tumor growth. The photograph showed the representative tumors from each group. Scale bar, 2 mm. Tumor weights from miR-497 overexpression group were significantly decreased compared to control group. Scale bar, 20 μm. (C) Immunohistochemistry (IHC) assay indicated that overexpression of miR-497 inhibited the expression levels of QKI and PCNA. (D) The expression levels of QKI from different tumor tissues as indicated were analyzed by immunoblotting. Data were representative of 3 independent experiments. * indicated significant difference at p<0.05, ** indicated significant difference at p<0.01.