Research Paper Volume 15, Issue 9 pp 3791—3806

Figure 1. miR-497 expression is down-regulated in the tumor tissues of EC patients. (A) Compared to adjacent normal tissues, the expression levels of miR-497 in EC tissues were significantly lower. (B, C) The result of CancerMIRNome (http://bioinfo.jialab-ucr.org/CancerMIRNome/) database showed that miR-497 levels were much lower in several types of cancer tissues, especially in esophageal cancer. (D) ROC curve showed that miR-497 may be used as a biomarker in EC prognosis. (E) Volcano plot of GSE114110 displayed differentially expressed microRNAs in normal and EC tissues. (F) Analysis of GSE43732 showed that miR-497 expression levels were significantly lower in EC samples. Data were representative of 3 independent experiments. * indicated significant difference at p<0.05, ** indicated significant difference at p<0.01, *** indicated significant difference at p <0.001; ns indicated p >0.05.