Research Paper Volume 15, Issue 9 pp 3690—3714

Figure 6. Contradistinction of genomic mutations in the two subgroups in the TCGA dataset. (A, B) Circos plots of low- and high-MGME1 subgroups show the amplifications and deletions of chromosomes, and the boxplots show a lower burden of copy number amplifications and deletions in the low-MGME1 subgroup. (C, D) The waterfall diagrams show the mutated genes in the low-MGME1 (C) and high-MGME1 (D) subgroups. (E, F) An association between MGME1 expression and TMB levels. (G, H) Association between TMB levels and the prognosis of patients with LGG (G) and the differential prognostic value in the two subtypes with different TMB level (H). ^*P < 0.05, ^**P < 0.01, ^***P < 0.001, ^****P < 0.0001.