Research Paper Volume 15, Issue 9 pp 3295—3330

Figure 5. GO terms of the molecular functions of the main deregulated clusters in the late-elderly group (group 4). (A) Molecular functions of GO-enrichment analysis reveals that the main altered proteins in clusters 1 and 7 in late-elderly are related to cell membranes functions, vesicle and synaptic functions, RNA binding, and structural components. (B) Deregulated phosphoproteins in clusters 4 and 8 in the late-elderly group are principally connected with cytoskeleton composition and regulation, kinase regulation and membrane stabilization. Although GO is referred to gene ontology, we have chosen the term number of proteins instead to avoid confusions.