Research Paper Volume 15, Issue 9 pp 3295—3330
Proteostatic modulation in brain aging without associated Alzheimer’s disease-and age-related neuropathological changes
Figure 1. Heatmaps representing differential proteins and phosphopeptides at proteome (A) and phosphoproteome (B), respectively, across all age groups. A total of 308 differentially expressed proteins and 465 differential phosphopeptides were identified when comparing all groups (ANOVA significant, p < 0.05). Among them, 280 proteins and 278 phosphopeptides were common to all groups in proteome and phosphoproteome analysis (p < 0.05). Only 28 proteins with altered expression levels also showed deregulated phosphorylation. Increased levels are indicated in the red spectrum, whereas decreased levels in the green spectrum.