Research Paper Volume 15, Issue 9 pp 3621—3634
Ling Zhi-8, a fungal immunomodulatory protein in Ganoderma lucidum, alleviates CPT-11-induced intestinal injury via restoring claudin-1 expression
Figure 6. Restoration of claudin-1 expression in the intestinal membranes by LZ-8 treatment in mice with CPT-11-induced intestinal injury, assessed by immunohistochemical staining. (A) The small intestine sections (40× and 200×). (B) The colon sections (40× and 200×). Homogeneous strong membrane staining (3+) was noted in the control and LZ groups. The intensity diminished in the CPT group, only 1+ in the small intestine section (arrowhead) and 2+ in the colon section (arrowhead). Compared to the CPT group, the intensity increased in the LZ+CPT group, showing 2+ in the small intestine section (arrowhead) and 3+ in the colon section (arrowhead).