Research Paper Volume 15, Issue 9 pp 3498—3523
A novel methionine metabolism-related signature predicts prognosis and immunotherapy response in lung adenocarcinoma
Figure 4. TME and immunological characteristics in distinct MRG modification patterns. (A, B) The differences of indicated TME characteristics (immune score, stromal score, and tumor purity) among three MRG modification patterns. The TME score was evaluated using the xCELL (A) and ESTIMATE (B) algorithm, respectively. (C) The differences of indicated TME-related signatures among three MRG modification patterns. The fold change between each subtype and the remaining samples were compared using the Wilcoxon rank sum test. The color of the dots indicates fold changes (log2) and size indicates the FDR values. (D) The differences of indicated immune cells among three MRG modification patterns. The relative cell abundances were calculated using 6 deconvolution algorithms as indicated. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001; ns, not significant.