Research Paper Volume 15, Issue 9 pp 3249—3272

Figure 1. Univariate unconditional associations of four SNPs from the MLXIPL gene with four continuous traits, TG (mg/dL), HDL-C (mg/dL), LDL-C (mg/dL), and LDL-C (mg/dL) in two samples drawn from US cohorts (A) and UK biobank (B). Two set of SNPs with different patterns of the associations are observed. The first (second) set, which include rs1051921 and rs17145750 (rs6967028 and rs11760752) demonstrate significant associations with higher (lower) levels of TG and lower (higher) levels of HDL-C. The Y-axis shows the effect sizes (beta) of the associations of respective SNPs with the outcomes depicted on the X axis. The X-axis shows the outcome variable used in the model. The vertical solid lines indicate 95% confidence intervals (CIs). Asterisks indicate different levels of significance, i.e., ^*5 × 10⁻⁴ ≤ p < 0.05; ^**5 × 10⁻⁶ ≤ p < 5 × 10⁻⁴; ^***5 × 10⁻⁸ ≤ p < 5 × 10⁻⁶; ^****p < 5 × 10⁻⁸.