Research Paper Volume 15, Issue 8 pp 2970—2998
Ubiquitin-proteasome system-mediated ubiquitination modification patterns and characterization of tumor microenvironment infiltration, stemness and cellular senescence in low-grade glioma
Figure 5. Construction of ubiquitination modification characteristic signature. (A, B) Distinction in the UM-score between ubiquitination modification modes and gene clusters in TCGA-LGG cohorts. (C) Survival analyses for the UM-score groups based on 523 patients with low-grade glioma from TCGA-LGG cohort. (D) The forecast value of UM-score in patients among the TCGA-LGG cohorts (AUC: 0.867, 0.896, and 0.895; 1, 2, and 3-years overall survival). (E) Multivariate Cox regression analysis, which included the factors of UM-score, Age, Grade, Gender, IDH1 status and patient outcomes in the TCGA-LGG cohort. (F) Survival analyses for the high- and low-UM-score groups based on 592 patients with low-grade glioma from CGGA-LGG cohort. (G) Multivariate Cox regression analysis, which included the factors of UM-score, Age, Grade, Gender, IDH1 status and patient outcomes in the CGGA-LGG cohort. (H, I) Distinction in the UM-score between CSC-clusters and Senescence-clusters in TCGA-LGG cohorts.