Research Paper Volume 15, Issue 14 pp 6721—6735
Th1 promotes M1 polarization of intestinal macrophages to regulate colitis-related mucosal barrier damage
Figure 4. Effect of Th1 on the intestinal tissue pathology of mice. (A) H&E (n=5). Apparent inflammatory injury occurred in intestinal tissue of DSS group, along with evident goblet cell injury, while Th1 aggravated the injury and further destroyed the intestinal mucosal structure. (B) IHC (n=5). In TJ protein staining, the levels of ZO1 and Occludin significantly decreased, and Th1 further suppressed the expression of TJ proteins, and the difference was significant compared with DSS group.