Research Paper Volume 15, Issue 3 pp 630—649

Figure 2. Platelet depletion shifts plaque size distribution in APP-PS1 females. (A) Amyloid plaque pathology was assessed in thioflavin S stained brain sections. (B) Plaque size distribution (% of small, medium, and large plaques) was analyzed in the hippocampus, whole cortex, somatosensory (SS) and somatomotor (MO) cortex. (C) APP-PS1 platelet-depleted females showed a shift in the percentage of small (30–100 μm²) and medium-size (100–500 μm²) amyloid plaques in the hippocampus and a reduced percentage of small-size amyloid plaques in SS and MO. (D) No differences were observed in platelet-depleted males. Data are shown as mean ± SEM. Statistical analysis was performed by ordinary two-way ANOVA with Tukey’s multiple comparisons test (n = 8–9/treatment; “full forms” represent females and “empty forms” males). ^**p < 0.01; ^*p < 0.05. Scale bar: 1 mm (insert 100 μm).