Research Paper Volume 15, Issue 3 pp 601—616
Metformin use history and genome-wide DNA methylation profile: potential molecular mechanism for aging and longevity
Figure 1. Age acceleration between metformin users and nonusers among the diabetes group. Age acceleration was calculated using the Horvath epigenetic clock as DNAm age - chronological age. Metformin = 0: without history of metformin use, Metformin = 1: with history of metformin use. p = 0.11.