Research Paper Volume 15, Issue 1 pp 246—260
Mitoquinone shifts energy metabolism to reduce ROS-induced oxeiptosis in female granulosa cells and mouse oocytes
Figure 5. MitoQ regulates ROS-induced reprogramming of cellular energy metabolism. (A) Schematic diagram showing metabolic pathways and qPCR analysis of the levels of genes involved in glycolysis and the TCA cycle. (B) The heatmap showing metabolite levels of glycolysis and TCA cycle pathway by UHPLC- MS/MS analysis. (C) Measurements of ATP by flow cytometry. (D) qPCR analysis of AMH gene levels. *p < 0.05, **p < 0.01 and ***p < 0.001 compared to the control. #p < 0.05, ##p < 0.01 and ###p < 0.001 compared to ROS only.