Research Paper Volume 15, Issue 1 pp 134—147
A case-control study coupling with meta-analysis elaborates decisive association between IGF-1 rs35767 and osteoporosis in Asian postmenopausal females
Figure 3. Trial sequential analysis of IGF-1 and OP in Asian samples. We performed a TSA using a dominant model assumption, but replaced the allele count with the sample size (divided by 2). (A) rs35767 detailed settings: Significance level = 0.05; Power = 0.8; least extreme OR to be detected = 1.3; MAF=0.35; I2 (heterogeneity) = 0%. (B) rs2288377 detailed settings: Significance level = 0.05; Power = 0.8; least extreme OR to be detected = 1.3; MAF=0.29; I2 (heterogeneity) = 0%. (C) rs5742612 detailed settings: Significance level = 0.05; Power = 0.8; least extreme OR to be detected = 1.3; MAF = 0.29; I2 (heterogeneity) = 0%.