Moderate-vigorous physical activity attenuates premature senescence of immune cells in sedentary adults with obesity: a pilot randomized controlled trial

Xiang-Ke Chen; Chen Zheng; Stephen Heung-Sang Wong; Alvin Chun-Hang Ma

doi:doi:10.18632/aging.204458

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Research Paper Volume 14, Issue 24 pp 10137—10152

Moderate-vigorous physical activity attenuates premature senescence of immune cells in sedentary adults with obesity: a pilot randomized controlled trial

Figure 1. MVPA is independently and negatively correlated with senescent markers in immune cells of adults with obesity. (A) Correlation between chronological age and senescent markers (log₂-transformed p16^INK4a and p21^Cip1) in peripheral blood mononuclear cells (PBMCs). (B) Correlation between maximum oxygen consumption (VO₂max) and senescent markers in PBMCs. (C) Correlation between body mass index (BMI) or body fat and senescent markers in PBMCs. (D) Correlation between objectively measured physical behaviors, including moderate–vigorous physical activity (MVPA), standing, sedentary behaviors, sleep duration, and senescent markers in PBMCs.