Research Paper Volume 14, Issue 24 pp 10093—10106

Figure 8. MiR-337-3p induces proliferation, migration, and invasion in BC cells. MiR-337-3p expressions in (A) UMUC3 and (B) 5637 cells were increased by the miR-337-3p mimics transfection and decreased by miR-337-3p inhibitor transfection, compared with the NC group. Wound healing assays (magnification, ×100) and transwell invasion assays (magnification, ×200) revealed that after transfection of miR-337-3p inhibitor, the cell migration rates and invasive cell number of UMUC3 cells (C, D) and 5637 cells (E, F) were restrained, while miR-337-3p mimics transfection promoted migration and invasion of UMUC3 (C, D) and 5637 (E, F) cells. CCK8 assays indicated that overexpression of miR-337-3p promoted proliferation activities of UMUC3 (G, H) and 5637 (I, J) cells, while miR-337-3p inhibitor groups acted the opposite. ^*p < 0.05, ^**p < 0.01, ^***p < 0.001.