Research Paper Volume 14, Issue 24 pp 10081—10092
SALL4 activates PI3K/AKT signaling pathway through targeting PTEN, thus facilitating migration, invasion and proliferation of hepatocellular carcinoma cells
Figure 6. SALL4 promoted migrated and proliferative ability of hepatic cancer SMMC 7721 cells via modulating PI3K/AKT signals. (A) Changes in protein levels of PTEN, p-PI3K, p-Akt as well as total-PI3K, Akt and downstream proteins: MMP2 and MMP-9 in hepatoma cells, SALL4 mimic increased the phosphorylated-PI3K/AKT and MMP2, -9 consistent with decreased phosphorylated PTEN protein levels and the SALL4 inhibitor showed the opposite effects and SF1670 corrected these phenomenon or effects of SALLU. (B) Changes of protein expression levels of CyclinD, Cyclin A1, PCNA and P62 in hepatocellular carcinoma cells. n = 3/group, t test between two groups, and by one-way analysis of variance among groups. *p < 0.05, **p < 0.01 vs. NC group.