Research Paper Volume 14, Issue 24 pp 9980—10008
The prognostic value of NLRP1/NLRP3 and its relationship with immune infiltration in human gastric cancer
Figure 6. The correlation of NLRP1/NLRP3 with immune checkpoints in TIMER 2.0. (A) The expression scatterplots between NLRP1 and immune checkpoint genes (PCD1, r = 0.381, p = 1.53 × 10−14; CTLA4, r = 0.358, p = 6.20 × 10−13; LAG3, r = 0.301, p = 2.14 × 10−9; and TIM-3 r = 0.383, p = 1.17 × 10−14); (B) The expression scatterplots between NLRP3 and immune checkpoint genes (PCD1, r = 0.444, p = 9.89 × 10−20; CTLA4, r = 0.471, p = 2.44 × 10−22; LAG3, r = 0.424, p = 5.98 × 10−18; and TIM-3 r = 0.746, p = 1.49 × 10−68). (C) The single-gene co-expression heat map of NLRP1 and immune checkpoint genes (PCD1, r = 0.377, p < 0.001); CTLA4, r = 0.349, p < 0.001; LAG3, r = 0.288, p < 0.001; and TIM-3 r = 0.353, p < 0.001); (D) The single-gene co-expression heat map of NLRP3 and immune checkpoint genes (PCD1, r = 0.453, p < 0.001); CTLA4, r = 0.506, p < 0.001; LAG3, r = 0.433, p < 0.001; and TIM-3, r = 0.720, p < 0.001).