Early life exercise training and inhibition of <i>apoLpp</i> mRNA expression to improve age-related arrhythmias and prolong the average lifespan in <i>Drosophila melanogaster</i>

Meng Ding; Qiu Fang Li; Tian Hang Peng; Tong Quan Wang; Han Hui Yan; Chao Tang; Xiao Ya Wang; Yin Guo; Lan Zheng

doi:doi:10.18632/aging.204422

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Research Paper Volume 14, Issue 24 pp 9908—9923

Early life exercise training and inhibition of apoLpp mRNA expression to improve age-related arrhythmias and prolong the average lifespan in Drosophila melanogaster

Figure 3. Effects of fat body UAS-apoLpp^RNAi on lifespan. (A) Lifespan of different genotypes of flies. On the left is the flies′ survival rate (%), and on the right is the median survival of flies. The sample sizes of W¹¹¹⁸, LSP2-Gal4, and LSP2-Gal4>W¹¹¹⁸ were 202, 190, and 205. (B) Effects of fat body UAS-apoLpp^RNAi on lifespan. On the left is the flies′ survival rate (%), and on the right is the median survival of flies. The sample sizes of LSP2-Gal4>W¹¹¹⁸ and LSP2-Gal4>UAS-apoLpp^RNAi were 205 and 195. P-values for all survival curves were obtained from the log-rank test. For median survival, P-values were obtained from student t-tests or one-way ANOVA, and all values were expressed as mean ± SEM. ^*p < 0.05, ^**p < 0.01, ^***p < 0.001.