Research Paper Volume 14, Issue 22 pp 8944—8969
JAK2/STAT3 pathway mediates neuroprotective and pro-angiogenic treatment effects of adult human neural stem cells in middle cerebral artery occlusion stroke animal models
Figure 5. DEGs and biological processes associated with effects of ahNSCs. (A) DEGs among the primary cortical neurons in the control, OGD, and NSC-CM group was filtered out, and then hierarchical clustering was performed. (B) With 53 genes whose expression were up-regulated in the OGD + NSC-CM group compared to the OGD group (> 2, up-regulated genes) biological process clustering was performed. (C) Expression of the top eight up-regulated genes of the NSC-CM group was illustrated at heatmap. (D) High expression of the top eight up-regulated genes was examined by qRT-PCR (n = 3 per group). * P < 0.05 ** P < 0.01.