Research Paper Volume 14, Issue 21 pp 8688—8699
Efficacy of zinc carnosine in the treatment of colorectal cancer and its potential in combination with immunotherapy in vivo
Figure 7. Mass cytometry reflected the immune microenvironment of subcutaneous CRC tumors after PBS/ZnC treatment. (A) A total of 31 cell clusters were divided, and we defined the respective group. (B) TSNE plot showing distributions of 31 cell cluster in the respective sample. (C) The histogram showing the number of the respective cell cluster in different groups by mass cytometry. (D–H) TSNE plot showing the distribution of CD8+ PD1, CD8+ TIGIT, CD8+ CCR6, CD8+ IFNg, and CD8+ ICOS in subcutaneous CRC tumors in PBS and ZnC groups. (I) The histogram showing the expression of CD8+ PD1, CD8+ TIGIT, CD8+ CCR6, CD8+ IFNg, and CD8+ ICOS in PBS and ZnC groups.