Research Paper Volume 14, Issue 21 pp 8688—8699

Efficacy of zinc carnosine in the treatment of colorectal cancer and its potential in combination with immunotherapy in vivo

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Figure 5. ZnC reduced tumor growth and increased the efficiency of anti-PD1 monoclonal antibody in xenograft mice model. (A) Procedures for establishing subcutaneously tumor-bearing mice model. PD1 antibody was injected internationally every 3 days. The mice injected with PBS were as the control. (B) Picture display of the respective group (PBS, ZnC, anti-PD1, and anti-PD1+ZnC) of subcutaneous tumors. (C, D) The volume (C) and weight (D) statistics of subcutaneous tumors in the respective group. (E) Immunohistochemical results of Ki67, PD-L1, and CD8 expression in the respective group. **p < 0.01, ***P < 0.001,****p < 0.0001.