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Research Paper Volume 14, Issue 21 pp 8615—8632

IGF1 gene therapy in middle-aged female rats delays reproductive senescence through its effects on hypothalamic GnRH and kisspeptin neurons

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Figure 6. IGF1 gene therapy effect on the Iba1 immunopositive cells. (A and B) Quantification of Iba1 immunopositive cells. Error bars represent SD (Arcuate: NRAd-IGF1 = 8; NPBS = 4. AVPV: NRAd-IGF1 = 7; NPBS = 4). t test with Welch’s correction was used. Asterisks indicate significant (*p < 0.05) differences. Figure 6A post hoc power (1-β) analysis: 0.8211; Figure 6B post hoc power (1-β) analysis: 0.4876. (C–F) Immunohistochemistry for Iba1 of control (PBS) and experimental (RAd-IGF1) rat’s brain slides at a magnification of 40× (scale bars: 500 microns), with insets at a magnification of 600× (scale bars: 50 microns). Abbreviation: 3V: third ventricle.