Comprehensive analysis of prognostic significance of cadherin (CDH) gene family in breast cancer

Su-Chi Ku; Hsin-Liang Liu; Che-Yu Su; I-Jeng Yeh; Meng-Chi Yen; Gangga Anuraga; Hoang Dang Khoa Ta; Chung-Chieh Chiao; Do Thi Minh Xuan; Fidelia Berenice Prayugo; Wei-Jan Wang; Chih-Yang Wang

doi:doi:10.18632/aging.204357

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Research Paper Volume 14, Issue 20 pp 8498—8567

Comprehensive analysis of prognostic significance of cadherin (CDH) gene family in breast cancer

Figure 7. Genomic alterations of differentially expressed cadherin 1 (CDH1)/2/4/7/11/12/13/15 genes in breast cancer. (A) The cBioPortal database was used to reveal levels of gene amplification, deep deletions, and associated nucleotide substitutions of the CDH1/2/4/7/11/12/13/15 genes in breast cancer progression in the METABRIC dataset. (B) Correlation plot of the CDH1/2/4/7/11/12/13/15 genes in breast cancer (cBioPortal) database. Insignificant correlation values were displayed by crosses; p<0.01 was considered statistically significant. (C) Protein-protein interactions (PPIs) of CDH1/2/4/7/11/12/13/15 (STRING database). Highly interacting proteins were represented as hub protein nodes in the PPI network.